Activity of antibiotics against Fusarium and Aspergillus
- 24 October 2008
- journal article
- research article
- Published by BMJ in British Journal of Ophthalmology
- Vol. 93 (1), 116-119
- https://doi.org/10.1136/bjo.2008.142364
Abstract
Background/aims: To study the susceptibility of Fusarium and Aspergillus isolated from keratitis to amoxicillin, cefazolin, chloramphenicol, moxifloxacin, tobramycin and benzalkonium chloride (BAK). Methods: 10 isolates of Fusarium and 10 isolates of Aspergillus from cases of fungal keratitis at Aravind Eye Hospital in South India were tested using microbroth dilution for susceptibility to amoxicillin, cefazolin, chloramphenicol, moxifloxacin, tobramycin and BAK. The minimum inhibitory concentration (MIC) median and 90th percentile were determined. Results: BAK had the lowest MIC for both Fusarium and Aspergillus. Chloramphenicol had activity against both Fusarium and Aspergillus, while moxifloxacin and tobramycin had activity against Fusarium but not Aspergillus. Conclusions: The susceptibility of Fusarium to tobramycin, moxifloxacin, chloramphenicol and BAK and of Aspergillus to chloramphenicol and BAK may explain anecdotal reports of fungal ulcers that improved with antibiotic treatment alone. While some of the MICs of antibiotics and BAK are lower than the typically prescribed concentrations, they are not in the range of antifungal agents such as voriconazole, natamycin and amphotericin B. Antibiotics may, however, have a modest effect on Fusarium and Aspergillus when used as initial treatment prior to identification of the pathological organism.Keywords
This publication has 16 references indexed in Scilit:
- Pleiotropic Actions of AminoglycosidesAntibiotics and chemotherapy, 2015
- Voriconazole in the treatment of fungal eye infections: a review of current literatureBritish Journal of Ophthalmology, 2008
- Aetiological diagnosis of microbial keratitis in South India - a study of 1618 cases.2007
- Clinical Response of Contact Lens-Associated Fungal Keratitis to Topical Fluoroquinolone TherapyCornea, 2007
- An Outbreak of Fusarium Keratitis Associated With Contact Lens Wear in SingaporeJAMA, 2006
- In vitro testing of fungicidal activity of biocides against Aspergillus fumigatusJournal of Medical Microbiology, 2005
- Fungal keratitisCurrent Opinion in Opthalmology, 2004
- Has Antifungal Susceptibility Testing Come of Age?Clinical Infectious Diseases, 2002
- Epidemiology and aetiological diagnosis of corneal ulceration in Madurai, south IndiaBritish Journal of Ophthalmology, 1997
- Antibiotic inhibition of pectolytic and cellulolytic enzyme activity in twoFusarium speciesMycopathologia, 1993