Commissural afferents innervate glutamate decarboxylase immunoreactive non-pyramidal neurons in the guinea pig hippocampus
- 1 May 1984
- journal article
- research article
- Published by Elsevier BV in Neuroscience Letters
- Vol. 46 (2), 137-143
- https://doi.org/10.1016/0304-3940(84)90431-2
Abstract
The innervation of GABAergic hippocampal neurons by commissural fibers was investigated in the guinea pig by a combined anterograde degeneration-immunocytochemical technique. Presumed GABAergic neurons were identified by immunocytochemistry for glutamate decarboxylase (GAD) and the commissural fibers by electron-dense degeneration following contralateral transection of the fimbria. Commissural afferents establish asymmetric synaptic contacts with non-pyramidal GAD-immunoreactive neurons located in subpyramidal and suprapyramidal zones of the region CA1. Evidently, the inhibition of pyramidal cells may occur in a feed-forward manner as postulated by electrophysiological studies.This publication has 26 references indexed in Scilit:
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