A Randomized, Blinded Comparison of Chioral Hydrate and Midazolam Sedation in Children Undergoing Echocardiography
- 1 July 2001
- journal article
- clinical trial
- Published by SAGE Publications in Clinical Pediatrics
- Vol. 40 (7), 381-387
- https://doi.org/10.1177/000992280104000704
Abstract
The objective of this prospective, randomized, and blinded study was to compare the use of chloral hydrate versus oral midazolam sedation in children undergoing echocardiography. No adverse effects (nausea, vomiting, paradoxical agitation, or significant deviations from baseline vital signs) were noted with either medication. No differences were noted in onset of sedation between the 2 groups, however, the time to complete recovery was significantly shorter with midazolam than with chloral hydrate. The children in the chloral hydrate group had a significantly deeper level of sedation and were more likely to receive a more nearly comprehensive echocardiographic evaluation.Keywords
This publication has 17 references indexed in Scilit:
- Safety and efficacy of chloral hydrate sedation in children undergoing echocardiographyThe Journal of Pediatrics, 1996
- Sedation in pediatric imaging using intranasal midazolamPediatric Radiology, 1995
- Intranasal Midazolam in Pediatric Conscious SedationAnnals of Emergency Medicine, 1995
- Oral chloral hydrate provides effective and safe sedation in paediatric magnetic resonance imagingJournal of Clinical Pharmacy & Therapeutics, 1994
- Oral midazolam premedication for children with congenital cyanotic heart disease under-going cardiac surgery: a comparative studyCanadian Journal of Anesthesia/Journal canadien d'anesthésie, 1993
- High-dose chloral hydrate sedation for children undergoing MR imaging: safety and efficacy in relation to age.American Journal of Roentgenology, 1993
- Midazolam nose drops for outpatient echocardiography sedation in infantsAmerican Heart Journal, 1991
- Efficacy of Sedation of Children With Chloral Hydrate*Southern Medical Journal, 1990
- Chloral HydrateAnesthesia & Analgesia, 1986
- The choice of sedation for computed tomography in children: a prospective evaluation.Radiology, 1982