Prospective assessment of health-related quality of life in patients with low-grade glioma
- 8 October 2011
- journal article
- clinical trial
- Published by Springer Science and Business Media LLC in Supportive Care in Cancer
- Vol. 20 (8), 1859-1868
- https://doi.org/10.1007/s00520-011-1288-4
Abstract
The assessment of Health-Related Quality of Life (HRQoL) in cancer patients has become increasingly important during the past decades. The aim of this study was to evaluate the HRQoL in patients treated for low-grade glioma (LGG). Forty-three adult patients with LGG were evaluated prospectively between September 2006 and December 2010. We assessed HRQoL at baseline (after surgery before radiotherapy), at the end of radiotherapy and during follow-up (every 3 months for the first 2 years and every 6 months between 2 and 5 years), using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire 30 (EORTC-C30), Brain Cancer Module-20 (BN-20), Mini Mental State Examination (MMSE) and Hospital Anxiety and Depression Scale (HADS). We demonstrated changes in global score (p = 0.004), and future uncertainty (p < 0.001), communication deficit (p = 0.007), headache (p < 0.001), drowsiness (p = 0.002) and hair loss (p < 0.001), and recall score (p = 0.0029) during follow-up. All complaints of LGG patients showed improvement, except for the hair loss. Although the baseline cognitive function scores was not significantly different, the third-year cognitive function scores of patients who used antiepileptic drugs had lower when compared to patients who did not use (p < 0.001). The baseline and follow-up anxiety and depression scores did not differ significantly. Our results suggested that there were improvement in HRQoL in LGG patients during follow-up and antiepileptic drugs had negative effect on cognitive functions.This publication has 42 references indexed in Scilit:
- Review on Quality of Life Issues in Patients with Primary Brain TumorsThe Oncologist, 2010
- Measuring Quality of Life in Routine Oncology Practice Improves Communication and Patient Well-Being: A Randomized Controlled TrialJournal of Clinical Oncology, 2004
- Effect of disease burden on health-related quality of life in patients with malignant gliomasNeuro-Oncology, 2000
- The creation of protection and hope in patients with malignant brain tumoursSocial Science & Medicine (1982), 1996
- Cognitive functions and quality of life in patients with low‐grade gliomas: The impact of radiotherapyAnnals of Neurology, 1994
- Cross-cultural adaptation of health-related quality of life measures: Literature review and proposed guidelinesJournal of Clinical Epidemiology, 1993
- The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in OncologyJNCI Journal of the National Cancer Institute, 1993
- Radiation‐induced dementia in patients cured of brain metastasesNeurology, 1989
- The quality of life of cancer patients: A review of the literatureSocial Science & Medicine (1982), 1985
- The Hospital Anxiety and Depression ScaleActa Psychiatrica Scandinavica, 1983