A new alkaloid AM-2282 of Streptomyces origin taxonomy, fermentation, isolation and preliminary characterization.

Abstract

AM-2282, a new alkaloid was isolated from cultures of Streptomyces sp. AM-2282 by solvent extraction and silica gel chromatography. The compound exhibits a strong absorption maximum at 292 nm and shows antimicrobial activity against fungi and yeast. The LD50 of its hydrochloride (i.p. in mice) is 6.6 mg/kg. The molecular formula of AM-2282 was determined as C28H26N4O3. The producing strain, AM-2282 was classified as a new species and the name, S. staurosporeus Awaya, Takahashi and Omura, nov. sp. is proposed.