Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice

Abstract

SARM1 triggers acute axon loss in response to trauma. Geisler et al. show that SARM1 is also required for the development of vincristine-induced peripheral neuropathy (VIPN) in mice. Targeting SARM1 or its downstream effectors may be a viable therapeutic option to prevent VIPN and possibly other peripheral neuropathies.