Synthesis and Anti-Candida Activity of Cobalt(II) Complexes of Benzene-1,2-Dioxyacetic Acid (bdoaH2). X-Ray Crystal Structures of [Co(bdoa)(H2O)3]⋅3.5H2O and {[CO(phen)3](bdoa)}2⋅24H2O (phen = 1,10-Phenanthroline)
Open Access
- 1 January 1999
- journal article
- Published by Hindawi Limited in Metal-Based Drugs
- Vol. 6 (1), 41-48
- https://doi.org/10.1155/MBD.1999.41
Abstract
reacts with benzene-1,2-dioxyacetic acid to give the complexes (1a) and (1b). Subsequent reaction of 1a with 1,10- phenanthroline produces (2a) and (2b). Molecular structures of 1b and 2b were determined crystallographically. In 1b the ligates the metal by two carboxylate oxygens and two ethereal oxygens, whereas in 2b the is uncoordinated. The and complexes (3) and (4) were also synthesised, 1a-4 and other metal complexes of bdoa (metal = Mn2+, Co2+ ,Cu2+, Cu+ ) were screened for their ability to inhibit the growth ofhe yeast Candida albicans. Complexes incorporating the 1,10-phenanthroline ligand were the most active.