Effect of age, gender and calciotropic hormones on the relationship between vitamin D receptor gene polymorphisms and bone mineral density
- 10 February 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Journal of Clinical Nutrition
- Vol. 64 (4), 383-391
- https://doi.org/10.1038/ejcn.2010.5
Abstract
Background/Objectives: Hypovitaminosis D is a major public health problem worldwide and unexpectedly more so in sunny countries. Vitamin D receptor (VDR) gene is associated with inter-individual variance in bone mineral density (BMD). Studies assessing the effect of VDR gene polymorphisms on BMD yielded conflicting results. The aim of this study was to assess the relationship between VDR polymorphisms and BMD in the Lebanese, across age groups and genders and to assess the effect of PTH and lean mass and vitamin D levels on such relationship. Subjects/Methods: In total, 203 subjects aged 65-85 years and 336 children aged 10-17 years. Polymorphisms in the VDR gene were assessed with the restriction enzymes BsmI, TaqI and ApaI. Bone mineral content, BMD and lean mass were measured using Dual-Energy X-ray Absorptiometry (DXA). The dominant hand strength was measured in children. Results: Heterozygote genotype was the most frequent in both age groups. There was no difference in the frequency distribution of genotypes between the young and the elderly. No relationship between VDR genotypes and lean mass was found in either age group. Heterozygote boys had the lowest parathormone (PTH) and heterozygote elderly women had the highest BMD at the spine and forearm. Conclusions: In the Lebanese, the relationship between VDR polymorphisms and BMD differs by age. Survival does not seem to differ by VDR genotype. However, further studies are needed to assess the effect of VDR gene polymorphisms on mortality per se and time to mortality, not evaluated in this study. European Journal of Clinical Nutrition (2010) 64, 383-391; doi: 10.1038/ejcn.2010.5; published online 10 February 2010Keywords
This publication has 37 references indexed in Scilit:
- Rickets in the Middle East: Role of Environment and Genetic PredispositionJournal of Clinical Endocrinology & Metabolism, 2008
- Hypovitaminosis D osteopathy: Is it mediated through PTH, lean mass, or is it a direct effect?Bone, 2006
- The Association between Common Vitamin D Receptor Gene Variations and Osteoporosis: A Participant-Level Meta-AnalysisAnnals of Internal Medicine, 2006
- Vitamin D receptor gene start codon polymorphism (FokI) is associated with forearm bone mineral density and calcaneal ultrasound in Finnish adolescent boys but not in girlsJournal of Bone and Mineral Metabolism, 2004
- Vitamin D Receptor Alleles, Bone Mineral Density and Turnover in Postmenopausal Osteoporotic and Healthy WomenMedical Principles and Practice, 2004
- Vitamin D Receptor Expression in Human Muscle Tissue Decreases With AgeJournal of Bone and Mineral Research, 2004
- In Situ Detection of 1,25-dihydroxyvitamin D Receptor In human Skeletal Muscle TissueJournal of Molecular Histology, 2001
- Vitamin D Receptor Gene Fok1 Polymorphism Predicts Calcium Absorption and Bone Mineral Density in ChildrenJournal of Bone and Mineral Research, 1999
- Prevalence of Vitamin D Insufficiency in an Adult Normal PopulationOsteoporosis International, 1997
- Why are some genetic diseases common?Human Genetics, 1993