The effect of glycerol on the guinea-pig hydropic ear
- 1 October 1991
- journal article
- Published by Wiley in Clinical Otolaryngology
- Vol. 16 (5), 483-487
- https://doi.org/10.1111/j.1365-2273.1991.tb01045.x
Abstract
The aim of this paper was to investigate the effect of glycerol on experimental endolymphatic hydrops in guinea-pigs. The right endolymphatic sac and duct were obliterated through an extradural posterior fossa approach. Some animals received a 3 g/kg dose of glycerol for a period of 7 days, whereas others received the same dose for 30 days. The activity of glycerol was studied by investigating the volumetric changes in the scala media determined with a computerized planimeter. Glycerol induced a significant reduction of the hydrops showing its effectiveness and suggesting a strial metabolic responseKeywords
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