Macrophage heterogeneity in tissues: phenotypic diversity and functions
Open Access
- 15 October 2014
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 262 (1), 36-55
- https://doi.org/10.1111/imr.12223
Abstract
During development and throughout adult life, macrophages derived from hematopoietic progenitors are seeded throughout the body, initially in the absence of inflammatory and infectious stimuli as tissue-resident cells, with enhanced recruitment, activation, and local proliferation following injury and pathologic insults. We have learned a great deal about macrophage properties ex vivo and in cell culture, but their phenotypic heterogeneity within different tissue microenvironments remains poorly characterized, although it contributes significantly to maintaining local and systemic homeostasis, pathogenesis, and possible treatment. In this review, we summarize the nature, functions, and interactions of tissue macrophage populations within their microenvironment and suggest questions for further investigation.Keywords
Funding Information
- Medical Research Council
This publication has 141 references indexed in Scilit:
- Th1 Cell Induction in Lymph Nodes According to a Red-Blue Chemokine MapImmunity, 2012
- A Spatially-Organized Multicellular Innate Immune Response in Lymph Nodes Limits Systemic Pathogen SpreadCell, 2012
- Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent MannerNeuron, 2012
- CD169+ macrophages at the crossroads of antigen presentationTrends in Immunology, 2012
- Monocyte trafficking in acute and chronic inflammationTrends in Immunology, 2011
- Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolismEMBO Molecular Medicine, 2010
- Alternative Activation of Macrophages: Mechanism and FunctionsImmunity, 2010
- Matrix Metalloproteinases: Regulators of the Tumor MicroenvironmentCell, 2010
- Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligandEuropean Journal of Immunology, 2008
- F4/80, a monoclonal antibody directed specifically against the mouse macrophageEuropean Journal of Immunology, 1981