Exploring and exploiting chemistry at the cell surface
- 22 July 2011
- journal article
- Published by Springer Science and Business Media LLC in Nature Chemistry
- Vol. 3 (8), 582-589
- https://doi.org/10.1038/nchem.1090
Abstract
Engineering the surface chemistry of a material so that it can interface with cells is an extraordinarily demanding task. The surface of a cell is composed of thousands of different lipids, proteins and carbohydrates, all intricately (and dynamically) arranged in three dimensions on multiple length scales. This complexity presents both a challenge and an opportunity to chemists working on bioactive interfaces. Here we discuss how some of these challenges can be met with interdisciplinary material synthesis. We also review the most popular classes of functional molecules grafted on engineered surfaces and explore some alternatives that may offer greater flexibility and specificity. Finally, we discuss the emerging field of dynamic surfaces capable of stimulating and responding to cellular activity in real time.Keywords
This publication has 59 references indexed in Scilit:
- Engineering of a synthetic electron conduit in living cellsProceedings of the National Academy of Sciences of the United States of America, 2010
- Synthetic surfaces for human embryonic stem cell cultureJournal of Biotechnology, 2010
- High-Throughput Discovery of Synthetic Surfaces That Support Proliferation of Pluripotent CellsJournal of the American Chemical Society, 2010
- Heparan Sulfation–Dependent Fibroblast Growth Factor Signaling Maintains Embryonic Stem Cells Primed for Differentiation in a Heterogeneous StateThe International Journal of Cell Cloning, 2009
- Cell adhesion and polarisation on molecularly defined spacing gradient surfaces of cyclic RGDfK peptide patchesEuropean Journal of Cell Biology, 2008
- How Cells Tiptoe on Adhesive Surfaces before StickingBiophysical Journal, 2008
- The heparanome—The enigma of encoding and decoding heparan sulfate sulfationJournal of Biotechnology, 2007
- Nicholas Harold Lloyd Ridley. 10 July 1906 — 25 May 2001Biographical Memoirs of Fellows of the Royal Society, 2007
- THE NATURE AND ABUNDANCE OF HUMAN RED CELL SURFACE GLYCOPROTEINSInternational Journal of Immunogenetics, 1990
- Binding and spreading of hepatocytes on synthetic galactose culture surfaces occur as distinct and separable threshold responses.The Journal of cell biology, 1986