Glutathione in Escherichia coli is dispensable for resistance to H2O2 and gamma radiation
Open Access
- 1 November 1986
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 168 (2), 1026-1029
- https://doi.org/10.1128/jb.168.2.1026-1029.1986
Abstract
Escherichia coli devoid of glutathione (because of transposon insertions in the gshA gene) has normal resistance to H2O2, cumene hydroperoxide, heat, or ionizing radiation. Intracellular glutathione thus does not protect E. coli from such lethal oxidative damage. The use of gshA::Tn10 mutants also revealed a glutathione-independent, H2O2-inducible resistance to N-ethylmaleimide.Keywords
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