Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification
Top Cited Papers
- 25 April 2014
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Biotechnology
- Vol. 32 (6), 577-582
- https://doi.org/10.1038/nbt.2909
Abstract
No abstract availableKeywords
This publication has 32 references indexed in Scilit:
- In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sitesNucleic Acids Research, 2013
- CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activityNucleic Acids Research, 2013
- Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene ExpressionCell, 2013
- Multiplex Genome Engineering Using CRISPR/Cas SystemsScience, 2013
- Cas9–crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteriaProceedings of the National Academy of Sciences of the United States of America, 2012
- A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial ImmunityScience, 2012
- Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzymeGenome Research, 2012
- Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effectsNucleic Acids Research, 2012
- Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selectionNature Methods, 2011
- Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleasesNature Biotechnology, 2008