Isoindolinone enantiomers having affinity for the dopamine D4 receptor
- 1 June 1998
- journal article
- Published by Elsevier BV in Bioorganic & Medicinal Chemistry Letters
- Vol. 8 (12), 1499-1502
- https://doi.org/10.1016/s0960-894x(98)00252-2
Abstract
PD 108635 (1) was identified as a potent dopamine D4 ligand and we wanted to replace the benzylic alcohol with a metabolically more stable moiety. Investigations led to the discovery of a series of isoindolinones having D4 affinity.Keywords
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