Endorphins: Naloxone Fails to Alter Experimental Pain or Mood in Humans
- 10 March 1978
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 199 (4333), 1093-1095
- https://doi.org/10.1126/science.343250
Abstract
In 30 human subjects, experimental pain was produced by either ischemia or cold-water immersion. In a double-blind procedure, intravenous doses of up to 10 milligrams of naloxone hydrochloride in saline were indistinguishable from similarly administered saline alone. There were no effects on subjective pain ratings, finger plethysmograph recordings, or responses to mood-state questionnaires. These laboratory procedures do not activate any functionally significant pain-attenuating or mood-altering effect of endorphins.Keywords
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