5‐(N‐Arylnortropan‐3‐yl)‐ and 5‐(N‐Arylpiperidin‐4‐yl)‐2,4‐diaminopyrimidines. Novel Inhibitors of Dihydrofolate Reductase
- 18 June 1986
- journal article
- medicinal and-biological-chemistry
- Published by Wiley in Helvetica Chimica Acta
- Vol. 69 (4), 887-897
- https://doi.org/10.1002/hlca.19860690416
Abstract
No abstract availableKeywords
This publication has 10 references indexed in Scilit:
- Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogsJournal of Medicinal Chemistry, 1985
- Properties of Brodimoprim as an Inhibitor of Dihydrofolate ReductasesChemotherapy, 1984
- Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate.Journal of Biological Chemistry, 1982
- Crystal structure of avian dihydrofolate reductase containing phenyltriazine and NADPH.Journal of Biological Chemistry, 1982
- 6 Recent Progress in the Medicinal Chemistry of 2,4-DiaminopyrimidinesProgress in Medicinal Chemistry, 1982
- Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution techniqueAntimicrobial Agents and Chemotherapy, 1979
- Dihydrofolate reductase from Lactobacillus caSci. Stereochemistry of NADPH binding.Published by Elsevier BV ,1979
- The protein data bank: A computer-based archival file for macromolecular structuresJournal of Molecular Biology, 1977
- Circular dichroism of heterocyclohexan-4-onic systems—IITetrahedron, 1972
- Cycloalk-2-enones and α,β,α',β'-Cycloalkadienones. A. Synthesis. B. On the Direction of Bromination of 2-Substituted Cycloalkanones and Their KetalsThe Journal of Organic Chemistry, 1965