Interaction of nanoparticles and cell-penetrating peptides with skin for transdermal drug delivery
- 7 October 2010
- journal article
- review article
- Published by Taylor & Francis Ltd in Molecular Membrane Biology
- Vol. 27 (7), 247-259
- https://doi.org/10.3109/09687688.2010.522203
Abstract
Topical or transdermal drug delivery is challenging because the skin acts as a natural and protective barrier. Therefore, several methods have been examined to increase the permeation of therapeutic molecules into and through the skin. One approach is to use the nanoparticulate delivery system. Starting with liposomes and other vesicular systems, several other types of nanosized drug carriers have been developed such as solid lipid nanoparticles, nanostructured lipid carriers, polymer-based nanoparticles and magnetic nanoparticles for dermatological applications. This review article discusses how different particulate systems can interact and penetrate into the skin barrier. In this review, the effectiveness of nanoparticles, as well as possible mode of actions of nanoparticles, is presented. In addition to nanoparticles, cell-penetrating peptide (CPP)-mediated drug delivery into the skin and the possible mechanism of CPP-derived delivery into the skin is discussed. Lastly, the effectiveness and possible mechanism of CPP-modified nanocarriers into the skin are addressed.Keywords
This publication has 84 references indexed in Scilit:
- Translocation of cell penetrating peptide engrafted nanoparticles across skin layersBiomaterials, 2010
- Formulation, characterization and pulmonary deposition of nebulized celecoxib encapsulated nanostructured lipid carriersJournal of Controlled Release, 2010
- Pig skin structure and transdermal delivery of liposomes: A two photon microscopy studyJournal of Controlled Release, 2008
- Enhanced skin penetration of P20 phosphopeptide using protein transduction domainsEuropean Journal of Pharmaceutics and Biopharmaceutics, 2008
- The role of hair follicles in the percutaneous absorption of caffeineBritish Journal of Clinical Pharmacology, 2007
- Lipid vesicles for skin delivery of drugs: Reviewing three decades of researchInternational Journal of Pharmaceutics, 2007
- Biophysical and Biological Studies of End-Group-Modified Derivatives of Pep-1Biochemistry, 2005
- Oligocarbamate Molecular Transporters: Design, Synthesis, and Biological Evaluation of a New Class of Transporters for Drug DeliveryJournal of the American Chemical Society, 2002
- Interaction of liposomes with human skin in vitro — The influence of lipid composition and structureBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1996
- Liposomes - a selective drug delivery system for the topical route of administration I. Lotion dosage formLife Sciences, 1980