Direct cardiovascular effects of glucagon like peptide-1
Open Access
- 29 August 2013
- journal article
- Published by Springer Science and Business Media LLC in Diabetology & Metabolic Syndrome
- Vol. 5 (1), 47-13
- https://doi.org/10.1186/1758-5996-5-47
Abstract
Current gold standard therapeutic strategies for T2DM target insulin resistance or β cell dysfunction as their core mechanisms of action. However, the use of traditional anti-diabetic drugs, in most cases, does not significantly reduce macrovascular morbidity and mortality. Among emerging anti-diabetic candidates, glucagon like peptide-1 (GLP-1) based therapies carry special cardiovascular implications, exerting both direct as well as indirect effects. The direct cardiovascular effects of GLP-1 and its analogs remain the focus of this review.Keywords
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