Levels of Pancreatic Glucagon, Insulin and Glucose during Twenty-Four Hours of the Day in Normal Subjects

Abstract

Plasma pancreatic glucagon, insulin and glucose were measured hourly in four healthy adult subjects during 24 hrs of the day. Plasma glucose and insulin levels increased after each meal and were invariable during night. The increase of plasma insulin after supper was not so remarkable as that after breakfast irrespective of its higher blood sugar level confirming a lower glucose tolerance in the evening. Plasma pancreatic glucagon showed a fairly constant level during day and night in normal subjects just as the total glucagon level reported by others.