Oleuropein in Olive and its Pharmacological Effects
Open Access
- 1 January 2010
- journal article
- Published by MDPI AG in Scientia Pharmaceutica
- Vol. 78 (2), 133-154
- https://doi.org/10.3797/scipharm.0912-18
Abstract
Olive from Olea europaea is native to the Mediterranean region and, both the oil and the fruit are some of the main components of the Mediterranean diet. The main active constituents of olive oil include oleic acid, phenolic constituents, and squalene. The main phenolic compounds, hydroxytyrosol and oleuropein, give extra-virgin olive oil its bitter, pungent taste. The present review focuses on recent works that have analyzed the relationship between the major phenolic compound oleuropein and its pharmacological activities including antioxidant, anti-inflammatory, anti-atherogenic, anti-cancer activities, antimicrobial activity, antiviral activity, hypolipidemic and hypoglycemic effect.Keywords
This publication has 65 references indexed in Scilit:
- Anti-proliferative and apoptotic effects of oleuropein and hydroxytyrosol on human breast cancer MCF-7 cellsCytotechnology, 2009
- tabAnti-HER2 (erbB-2) oncogene effects of phenolic compounds directly isolated from commercial Extra-Virgin Olive Oil (EVOO)BMC Cancer, 2008
- Characterization of new phenolic compounds from leaves of Olea europaea L. by high‐resolution tandem mass spectrometryRapid Communications in Mass Spectrometry, 2007
- Olive oil's bitter principle reverses acquired autoresistance to trastuzumab (Herceptin™) in HER2-overexpressing breast cancer cellsBMC Cancer, 2007
- Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: Part I. Integrase inhibitionBiochemical and Biophysical Research Communications, 2007
- Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbitsLife Sciences, 2006
- Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptorBiochemical and Biophysical Research Communications, 2005
- Effects of virgin olive oil phenolics on scavenging of reactive nitrogen species and upon nitrergic neurotransmissionLife Sciences, 2001
- Olive Oils Rich in Natural Catecholic Phenols Decrease Isoprostane Excretion in HumansBiochemical and Biophysical Research Communications, 2000
- The effect of the olive phenolic compound, oleuropein, on growth and enterotoxin B production by Staphylococcus aureusJournal of Applied Bacteriology, 1993