Transformation of the proteasome with age-related macular degeneration
- 2 February 2007
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 581 (5), 885-890
- https://doi.org/10.1016/j.febslet.2007.01.061
Abstract
The proteasome mediates pathways associated with oxidative stress and inflammation, two pathogenic events correlated with age-related macular degeneration (AMD). In human donor eyes corresponding to four stages of AMD, we found the proteasomal chymotrypsin-like activity increased in neurosensory retina with disease progression. Increased activity correlated with a dramatic increase in the inducible subunits of the immunoproteasome, which was not due to an increase in CD45 positive immune cells in the retina. The novel observation of proteasome transformation may reflect retinal response to local inflammation or oxidative stress with AMD.This publication has 31 references indexed in Scilit:
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