Total homocysteine and cardiovascular disease
Open Access
- 1 November 1999
- journal article
- review article
- Published by Wiley in Journal of Internal Medicine
- Vol. 246 (5), 425-454
- https://doi.org/10.1046/j.1365-2796.1999.00512.x
Abstract
Nygård O, Vollset SE, Refsum H, Brattström L, Ueland PM (University of Bergen, Norway; County Hospital, Kalmar, Sweden). Total homocysteine and cardiovascular disease (Review). J Intern Med 1999; 246: 425–454. Recent data have shown that an elevated plasma level of the amino acid homocysteine (Hcy) is a common, independent, easily modifiable and possibly causal risk factor for cardiovascular disease (CVD) which may be of equal importance to hypercholesterolemia, hypertension and smoking. This paper reviews the biochemical, clinical, epidemiological and experimental data underlying this conclusion and is critically questioning whether elevated tHcy is a causal factor.Keywords
This publication has 155 references indexed in Scilit:
- Increased postprandial homocysteinemia in a group of depressed patientsAmino Acids, 1997
- Determination of Plasma Total Homocysteine and Cysteine Using HPLC with Fluorescence Detection and an Ammonium 7-fluoro-2,1,3-benzoxadiazole-4-sulphonate (SBD-F) Derivatization Protocol Optimized for Antioxidant Concentration, Derivatization Reagent ConceBiomedical Chromatography, 1996
- Efficacy and safety of cholestyramine therapy in peripubertal and prepubertal children with familial hypercholesterolemiaThe Journal of Pediatrics, 1996
- Homocysteine response to methionine challenge in four obligate heterozygotes for homocystinuria and relationship with cystathionine β ‐synthase mutationsJournal of Inherited Metabolic Disease, 1995
- Oxidation of low-density lipoprotein by thiol compounds leads to its recognition by the acetyl LDL receptorBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1987
- Protein-Bound Homocyst(e)ine in Patients With Rheumatoid Arthritis Undergoing D-Penicillamine TreatmentThe Journal of Clinical Pharmacology, 1986
- Homocystinuria associated with decreased methylenetetrahydrofolate reductase activityBiochemical and Biophysical Research Communications, 1972
- Homocystinuria: Metabolic studies on 3 patientsThe Journal of Pediatrics, 1965
- Homocystinuria: Clinical and pathological review of ten casesThe Journal of Pediatrics, 1965
- The identification of homocystine in the urineBiochemical and Biophysical Research Communications, 1962