National Cancer Data Base report on malignant paragangliomas of the head and neck
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- 31 January 2002
- Vol. 94 (3), 730-737
- https://doi.org/10.1002/cncr.10252
Abstract
BACKGROUND Malignant paragangliomas of the head and neck are rare, with previous reports limited to nine or fewer patients. The current review included 59 cases extracted from the National Cancer Data Base that were diagnosed between 1985–1996. METHODS The primary criterion for inclusion in the current study was verified metastatic spread from a paraganglioma of the head and neck. Patterns of presentation and treatment as well as clinically relevant associations were demonstrated in contingency tables. Relative survival was used for analysis of outcome. RESULTS The average patient age at presentation was 44 years, and gender distribution was equivalent. Metastases were confined to regional lymph nodes in the majority of cases (68.6%), with carotid body tumors found to have an even higher rate of regional confinement (93.8%). Surgery was the most common treatment (76.3%). The use of adjuvant irradiation for regionally confined disease increased across time, from 27% (1985–1990) to 46% (1991–1996). The 5-year relative survival rate was 59.5% (76.8% for regionally confined carcinoma and 11.8% for distant metastasis). Among patients who were followed until death, those treated with adjuvant irradiation had a longer median survival (45 months) compared with those patients who were treated with surgery alone (12 months). CONCLUSIONS Malignant paraganglioma represents metastatic spread of a tumor type that, when restricted to the site of origin, is considered benign. Metastases from malignant paragangliomas of the head and neck usually are regionally confined. The primary management of a recognized malignancy should be directed toward complete surgical removal of the primary tumor and regional lymph nodes. Postoperative irradiation may be beneficial in slowing the progression of residual disease. Cancer 2002;94:730–7. © 2002 American Cancer Society. DOI 10.1002/cncr.10252Keywords
This publication has 22 references indexed in Scilit:
- Malignant Glomus TumorsThe Laryngoscope, 1999
- Malignant vagal paragangliomaThe Journal of Laryngology & Otology, 1997
- Paragangliomas of the carotid bifurcation: oncological aspects of vascular surgeryEuropean Journal of Surgical Oncology, 1996
- Carotid body tumours and other cervical paragangliomas: Diagnosis and management in 25 patientsBritish Journal of Surgery, 1989
- The histopathological and clinical features of irradiated and nonirradiated temporal paragangliomasThe Laryngoscope, 1988
- Metastatic intravagal paraganglioma. Case report and review of the literatureThe American Journal of Medicine, 1985
- Carotid body paraganglioma with metastases.The Laryngoscope, 1985
- Carotid Body Tumors: A I 6-Year Follow-up of Seven Malignant CasesSouthern Medical Journal, 1973
- Glomus jugulare tumorsThe Laryngoscope, 1962
- TUMORS OF THE CAROTID BODY. CLINICAL AND PATHOLOGIC CONSIDERATIONS OF TWENTY TUMORS AFFECTING NINETEEN PATIENTS (ONE BILATERAL)Annals of Surgery, 1941