Free Radical Activity in Type 2 Diabetes
- 1 January 1990
- journal article
- research article
- Published by Wiley in Diabetic Medicine
- Vol. 7 (1), 27-30
- https://doi.org/10.1111/j.1464-5491.1990.tb01302.x
Abstract
Free radical activity has been implicated in the development of diabetic vascular complications in Type 1 diabetes. The aim of the present study was to investigate the levels of free radical scavengers, particularly erythrocyte superoxide dismutase, plasma and erythrocyte lysate thiol, and caeruloplasmin in 22 Type 2 diabetic patients clinically free of complications, and 15 comparable non‐diabetic control subjects. The concentration (median (range)) of both superoxide dismutase (23 (10–39) vs 45 (25–75) μmol I−1; p < 0.001) and plasma thiol (374 (172–523) vs 460 (386–595) μmol I−1; p < 0.01) were reduced in the diabetic group. There were no significant differences in the concentration of erythrocyte lysate thiol (199 (114–520) vs 188 (114–328) μmol I−1) or plasma caeruloplasmin (18 (9–31) vs 24 (6–50) μmol I−1) between the groups. This reduction in superoxide dismutase and the imbalance in the redox status of the plasma and lysate thiol demonstrated is consistent with an increase in free radical activity in Type 2 diabetes.Keywords
This publication has 21 references indexed in Scilit:
- Lipid peroxides and atherosclerosis.BMJ, 1989
- Serum lipids, lipid peroxides and the care of children with high risk atherosclerotic family historyAtherosclerosis, 1987
- Increased Diene Conjugates in Diabetic Subjects with MicroangiopathyDiabetic Medicine, 1987
- Early and late changes in sulphydryl group and copper protein concentrations and activities during drug treatment with aurothiomalate and auranofin.Annals Of The Rheumatic Diseases, 1986
- Pharmacological intervention in acute myocardial ischemia and reperfusionTrends in Pharmacological Sciences, 1985
- Oxygen-Derived Free Radicals in Postischemic Tissue InjuryNew England Journal of Medicine, 1985
- AN APPROACH TO FREE RADICALSThe Lancet, 1983
- Serum copper and erythrocyte superoxide dismutase in rheumatoid arthritis.Annals Of The Rheumatic Diseases, 1982
- The Biology of Oxygen RadicalsScience, 1978
- Modification of a P-Phenylenediamine Oxidase Method to Permit Non-Automated Ceruloplasmin Determinations in Batches of Rat Serum or Plasma MicrosamplesAnalytical Letters, 1977