Serotonin promotes the proliferation of serum-deprived hepatocellular carcinoma cells via upregulation of FOXO3a
Open Access
- 1 January 2013
- journal article
- Published by Springer Science and Business Media LLC in Molecular Cancer
- Vol. 12 (1), 14
- https://doi.org/10.1186/1476-4598-12-14
Abstract
Peripheral serotonin is involved in tumorigenesis and induces a pro-proliferative effect in hepatocellular carcinoma (HCC) cells; however, the intracellular mechanisms by which serotonin exerts a mitogenic effect remain unclear. In this research, we examined whether FOXO3a, a transcription factor at the interface of crucial cellular processes, plays a role downstream of serotonin in HCC cells.Keywords
This publication has 47 references indexed in Scilit:
- Serotonin ReceptorsChemical Reviews, 2008
- Serotonin: a reviewJournal of Veterinary Pharmacology and Therapeutics, 2008
- Role of serotonin in the hepato-gastroIntestinal tract: an old molecule for new perspectivesCellular and Molecular Life Sciences, 2007
- The serotonin 5‐HT2Breceptor controls bone massviaosteoblast recruitment and proliferationThe FASEB Journal, 2007
- Platelet-Derived Serotonin Mediates Liver RegenerationScience, 2006
- Primary liver cancer: Worldwide incidence and trendsGastroenterology, 2004
- Multiplicity of mechanisms of serotonin receptor signal transductionPharmacology & Therapeutics, 2001
- A new role for an old molecule: serotonin as a mitogen.American Journal of Physiology-Lung Cellular and Molecular Physiology, 1997
- Ras Involvement in Signal Transduction by the Serotonin 5-HT2B ReceptorPublished by Elsevier BV ,1996
- The pharmacology and distribution of human 5‐hydroxytryptamine2B (5‐HT2b) receptor gene products: comparison with 5‐HT2a and 5‐HT2c receptorsBritish Journal of Pharmacology, 1995