Delivery of Doxorubicin from Biodegradable PEG Hydrogels Having Schiff Base Linkages†
- 1 November 2007
- journal article
- research article
- Published by SAGE Publications in Journal of Bioactive and Compatible Polymers
- Vol. 22 (6), 589-601
- https://doi.org/10.1177/0883911507084653
Abstract
In our quest to develop new drug delivery systems, we designed and synthesized PEG-conjugates and PEG-hydrogels with a degradable linkage to the drug. Specifically, methoxyPEG-doxorubicin (MPEG-CH=N-Doxo) and doxorubicin-PEG aldehyde (OHC-PEG-CH=N-Doxo) conjugates, plus poly (vinyl amine)-PEG-doxorubicin (PVAm-PEG-Doxo) hydrogels were prepared. The hydrogels were crosslinked by PEG-Schiff base linkages, and the Doxo was conjugated to the gel by pendant Schiff base bonds (PVAm-N=CH-PEG-CH=N-Doxo). The release profile of Doxo from the hydrogels was dependent on pH and on the ratio of PVAm to the PEG-dialdehyde crosslinker. These degradable PEG hydrogels could be good candidates for slow release of Doxo from subcutaneous or IM implants.Keywords
This publication has 23 references indexed in Scilit:
- Polymer conjugates as anticancer nanomedicinesNature Reviews Cancer, 2006
- Effect of pegylation on pharmaceuticalsNature Reviews Drug Discovery, 2003
- Bioinspired pH-Responsive Polymers for the Intracellular Delivery of Biomolecular DrugsBioconjugate Chemistry, 2003
- Peptide and protein PEGylation: a review of problems and solutionsBiomaterials, 2001
- PegylationClinical Pharmacokinetics, 2001
- Attachment of Degradable Poly(Ethylene Glycol) to Proteins has the Potential to Increase Therapeutic EfficacyJournal of Pharmaceutical Sciences, 1998
- Polyethylene glycol-conjugated pharmaceutical proteinsPharmaceutical Science & Technology Today, 1998
- Poly(ethylene glycol)Published by American Chemical Society (ACS) ,1997
- Chemistry of polyethylene glycol conjugates with biologically active moleculesAdvanced Drug Delivery Reviews, 1995
- Functionalized Poly(ethylene glycols) for Preparation of Biologically Relevant ConjugatesBioconjugate Chemistry, 1995