Correlation of umbilical cord blood hormones and growth factors with stem cell potential: implications for the prenatal origin of breast cancer hypothesis
Open Access
- 14 May 2007
- journal article
- Published by Springer Science and Business Media LLC in Breast Cancer Research
- Vol. 9 (3), R29
- https://doi.org/10.1186/bcr1674
Abstract
Prenatal levels of mitogens may influence the lifetime breast cancer risk by driving stem cell proliferation and increasing the number of target cells, and thereby increasing the chance of mutation events that initiate oncogenesis. We examined in umbilical cord blood the correlation of potential breast epithelial mitogens, including hormones and growth factors, with hematopoietic stem cell concentrations serving as surrogates of overall stem cell potential.Keywords
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