Transfer-Printing of Single DNA Molecule Arrays on Graphene for High-Resolution Electron Imaging and Analysis
- 16 September 2011
- journal article
- letter
- Published by American Chemical Society (ACS) in Nano Letters
- Vol. 11 (10), 4232-4238
- https://doi.org/10.1021/nl202219w
Abstract
Graphene represents the ultimate substrate for high-resolution transmission electron microscopy, but the deposition of biological samples on this highly hydrophobic material has until now been a challenge. We present a reliable method for depositing ordered arrays of individual elongated DNA molecules on single-layer graphene substrates for high-resolution electron beam imaging and electron energy loss spectroscopy analysis. This method is a necessary step toward the observation of single elongated DNA molecules with single base spatial resolution to directly read genetic and epigenetic information.Keywords
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