Efficacy of different dry eye treatments with artificial tears or ocular lubricants: a systematic review
- 9 October 2009
- journal article
- review article
- Published by Wiley in Ophthalmic and Physiological Optics
- Vol. 29 (6), 573-583
- https://doi.org/10.1111/j.1475-1313.2009.00683.x
Abstract
To objectively review the outcome of clinical studies where rose bengal stain (RB) has been used as an outcome measure to assess the efficacy of artificial tears (AT) in patients with dry eye. From peer-reviewed articles published between 1947 and 2008, information was sought on dry eye status, as reported using a grading scheme, after use of RB as a diagnostic test, before and after use of a specific regimen of artificial tears or ocular lubricants for approximately 30 days. Mean baseline scores and post-treatment scores were calculated, along with the net change and the percentage change in the RB scores. From a total of 33 suitable data sets, published between 1985 and 2006, the group mean pre-treatment RB score was 4.25 +/- 1.55 (+/-S.D.), which decreased to 2.84 +/- 1.24 after 30 days of treatment. This represented a net change of -1.43 (95% CI of -1.04 to -1.45). For use of traditional AT (saline, hypromellose, etc), the net change was -0.95, it was -1.33 for use of carbomer (polyacrylic acid) gels and -2.10 for hyaluronic acid (HA) products. These changes represented net improvements of 25.9 +/- 18.4%, 38.0 +/- 20.7% and 41.8 +/- 16.3% respectively. The greater change with HA was not associated with a lower final outcome score, but with higher pre-treatment scores. Based on RB grading schemes used by numerous different clinicians over many years, treatment of dry eye with artificial tears or ocular lubricants can be expected to improve the condition of the exposed ocular surface. Assuming no improvement without treatment, a 30 days treatment period can be projected to produce an overall improvement of around 25%, but with no unambiguous statistical differences between product types.Keywords
This publication has 31 references indexed in Scilit:
- An assessment of the discomfort associated with the use of rose bengal 1% eyedrops on the normal human eye: a comparison with saline 0.9% and a topical ocular anaestheticOphthalmic and Physiological Optics, 2007
- Clinical evaluation of the traditional chinese prescription Chi-Ju-Di-Huang-Wan for Dry EyePhytotherapy Research, 2005
- Efficacité et tolérance d’un gel de carbomère fluide versus un gel de carbomère classique lors du traitement du syndrome secJournal Français d'Ophtalmologie, 2004
- Grading Of Corneal and Conjunctival Staining in the Context of Other Dry Eye TestsCornea, 2003
- The comparison of efficacies of topical corticosteroids and nonsteroidal anti-inflammatory drops on dry eye patients: a clinical and immunocytochemical studyAmerican Journal of Ophthalmology, 2003
- Sodium hyaluronate eye drops of different osmolarity for the treatment of dry eye in Sjogren's syndrome patientsBritish Journal of Ophthalmology, 2002
- Long term treatment with sodium hyaluronate-containing artificial tears reduces ocular surface damage in patients with dry eyeBritish Journal of Ophthalmology, 2002
- Comparison of grading schemes to quantitative assessments of nucleus-to-cytoplasmic ratios for human bulbar conjunctival cells collected by impression cytologyCurrent Eye Research, 2000
- Double blind, randomised, placebo controlled, crossover, multicentre study to determine the efficacy of a 0.1% (w/v) sodium hyaluronate solution (Fermavisc) in the treatment of dry eye syndromeBritish Journal of Ophthalmology, 1999
- A Patient Questionnaire Approach to Estimating the Prevalence of Dry Eye Symptoms in Patients Presenting to Optometric Practices across CanadaOptometry and Vision Science, 1997