Long-term results of treating hepatic colorectal metastases with cryosurgery
- 1 June 2001
- journal article
- Published by Oxford University Press (OUP) in British Journal of Surgery
- Vol. 88 (6), 844-849
- https://doi.org/10.1046/j.1365-2168.2001.01766.x
Abstract
Background The purpose of this study was to determine the long-term efficacy of cryosurgery as an adjunct to hepatic resection in patients with colorectal liver metastases not amenable to resection alone. Methods Thirty patients met the following inclusion criteria: metastases confined to the liver and judged irresectable, ten or fewer metastases, cryosurgery alone or in combination with hepatic resection allowed tumour clearance. Results Median follow-up was 26 (range 9–73) months. Overall 1- and 2-year survival rates were 76 and 61 per cent respectively. Median survival was 32 months. Disease-free survival at 1 year was 35 per cent, at 2 years 7 per cent. Six patients developed recurrence at the site of cryosurgery; given that the total number of cryosurgery-treated lesions was 69 the local recurrence rate was 9 per cent. Conclusion In patients with colorectal liver metastases, local ablative techniques can be used as an effective adjunct to hepatic resection to obtain tumour clearance.Keywords
This publication has 26 references indexed in Scilit:
- Hepatic Arterial Infusion of Chemotherapy after Resection of Hepatic Metastases from Colorectal CancerNew England Journal of Medicine, 1999
- Randomized Trial of Surgery Versus Surgery Followed by Adjuvant Hepatic Arterial Infusion With 5-Fluorouracil and Folinic Acid for Liver Metastases of Colorectal CancerAnnals of Surgery, 1998
- Place of Cryosurgery in the Treatment of Malignant Liver TumorsAnnals of Surgery, 1997
- Resection of Nonresectable Liver Metastases from Colorectal Cancer After Neoadjuvant ChemotherapyAnnals of Surgery, 1996
- Cryoablation of unresectable malignant liver tumorsThe American Journal of Surgery, 1996
- Hepatic cryosurgery in treating colorectal metastasesCancer, 1995
- Resection of colorectal liver metastasesWorld Journal of Surgery, 1995
- Ultrasound-guided hepatic cryosurgery in the treatment of metastatic colon carcinoma. Preliminary resultsCancer, 1991
- Hepatic metastases from colorectal carcinoma: Impact of surgical resection on the natural historyBritish Journal of Surgery, 1990
- Hepatic Resection for Colorectal Liver MetastasesAnnals of Surgery, 1987