Regulation of ceramide channels by Bcl‐2 family proteins
- 14 February 2010
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 584 (10), 2128-2134
- https://doi.org/10.1016/j.febslet.2010.02.032
Abstract
Mitochondrial outer membrane permeabilization to proteins, an irreversible step in apoptosis by which critical proteins are released, is tightly regulated by Bcl-2 family proteins. The exact nature of the release pathway is still undefined. Ceramide is an important sphingolipid, involved in various cellular processes including apoptosis. Here we describe the structural properties of ceramide channels and their regulation by the anti-apoptotic and pro-apoptotic proteins of the Bcl-2 family. The evolutionarily conserved regulation of ceramide channels by Bcl-2 family proteins, consistent with their role in apoptosis, lends credibility to the notion that ceramide channels constitute the protein release pathway.Keywords
This publication has 49 references indexed in Scilit:
- The BCL-2 Protein BAK Is Required for Long-chain Ceramide Generation during ApoptosisPublished by Elsevier BV ,2010
- Ceramide Generated by Sphingomyelin Hydrolysis and the Salvage Pathway Is Involved in Hypoxia/Reoxygenation-induced Bax Redistribution to Mitochondria in NT-2 CellsPublished by Elsevier BV ,2008
- Bcl-XL Inhibits Membrane Permeabilization by Competing with BaxPLoS Biology, 2008
- Analysis of endogenous Bax complexes during apoptosis using blue native PAGE: implications for Bax activation and oligomerizationBiochemical Journal, 2008
- Anti-apoptotic Bcl-2 Family Proteins Disassemble Ceramide ChannelsJournal of Biological Chemistry, 2008
- Principles of bioactive lipid signalling: lessons from sphingolipidsNature Reviews Molecular Cell Biology, 2008
- The N-terminal conformation of Bax regulates cell commitment to apoptosisCell Death & Differentiation, 2007
- Sphingosine, a Product of Ceramide Hydrolysis, Influences the Formation of Ceramide ChannelsBiophysical Journal, 2006
- Identification of mouse sphingomyelin synthase 1 as a suppressor of Bax-mediated cell death in yeastFEMS Yeast Research, 2006
- Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminalsProceedings of the National Academy of Sciences of the United States of America, 2004