Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy
Top Cited Papers
Open Access
- 16 July 2017
- journal article
- review article
- Published by Hindawi Limited in Journal of Diabetes Research
- Vol. 2017, 1-10
- https://doi.org/10.1155/2017/2615286
Abstract
Diabetic nephropathy (DN) together with glomerular hyperfiltration has been implicated in the development of diabetic microangiopathy in the initial stage of diabetic diseases. Increased amounts of urinary protein in DN may be associated with functional and morphological alterations of podocyte, mainly including podocyte hypertrophy, epithelial-mesenchymal transdifferentiation (EMT), podocyte detachment, and podocyte apoptosis. Accumulating studies have revealed that disruption in multiple renal signaling pathways had been critical in the progression of these pathological damages, such as adenosine monophosphate-activated kinase signaling pathways (AMPK), wnt/β-catenin signaling pathways, endoplasmic reticulum stress-related signaling pathways, mammalian target of rapamycin (mTOR)/autophagy pathway, and Rho GTPases. In this review, we highlight new molecular insights underlying podocyte injury in the progression of DN, which offer new therapeutic targets to develop important renoprotective treatments for DN over the next decade.Keywords
Funding Information
- National Science and Technology Major Project (81673907, Z161100000516024)
This publication has 96 references indexed in Scilit:
- Improving the Measurement of Semantic Similarity between Gene Ontology Terms and Gene Products: Insights from an Edge- and IC-Based Hybrid MethodPLOS ONE, 2013
- Rapamycin Upregulates Autophagy by Inhibiting the mTOR-ULK1 Pathway, Resulting in Reduced Podocyte InjuryPLOS ONE, 2013
- Wnt/β-Catenin Signaling and DiseaseCell, 2012
- Mechanisms of the proteinuria induced by Rho GTPasesKidney International, 2012
- Notch signaling in diabetic nephropathyExperimental Cell Research, 2012
- Mitochondrial Fission Triggered by Hyperglycemia Is Mediated by ROCK1 Activation in Podocytes and Endothelial CellsCell Metabolism, 2012
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1Nature, 2011
- Advanced glycation endproducts induce podocyte apoptosis by activation of the FOXO4 transcription factorKidney International, 2007
- Complex networks orchestrate epithelial–mesenchymal transitionsNature Reviews Molecular Cell Biology, 2006
- Alterations in the expression of the a 3 b 1 integrin in certain membrane domains of the glomerular epithelial cells (podocytes) in diabetes mellitusDiabetologia, 1997