Quantification of citrate concentration in the prostate by proton magnetic resonance spectroscopy: Zonal and age‐related differences
- 1 September 1996
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 36 (3), 352-358
- https://doi.org/10.1002/mrm.1910360305
Abstract
A commercial phased-array multicoil was used to acquire water-suppressed localized proton spectra of the two major anatomical regions of the prostate. The signal-to-noise ratio and spectral resolution allowed identification of peaks from choline and creatine, as well as a major peak from citrate. Quantification of the citrate peak using experimentally determined relaxation parameters with tissue water as an internal concentration reference revealed a marked variability between different volunteers. Nevertheless, in each case, the citrate concentration was up to fourfold greater in the peripheral zone than in the central gland. Furthermore, the difference in citrate concentration between these two regions was positively correlated with the subjects age. The results indicate a consistent difference in cellular function between the major anatomical regions within the prostate and may have important consequences for the application of magnetic resonance spectroscopy to the diagnosis of prostatic pathology.Keywords
This publication has 20 references indexed in Scilit:
- Determination of proton metabolite concentrations and relaxation parameters in normal human brain and intracranial tumoursNMR in Biomedicine, 1995
- Density matrix calculations of AB spectra from multipulse sequences: Quantum mechanics meets In vivo spectroscopyConcepts in Magnetic Resonance, 1994
- In vitro high resolution 1h‐spectroscopy of the human prostate: Benign prostatic hyperplasia, normal peripheral zone and adenocarcinomaMagnetic Resonance in Medicine, 1993
- Localized proton MR spectroscopy of citrate in vitro and of the human prostate in vivo at 1.5 TMagnetic Resonance in Medicine, 1993
- Magnetic resonance spectroscopy in prostate disease: Diagnostic possibilities and future developmentsThe Prostate, 1992
- Concepts of citrate production and secretion by prostate: 2. Hormonal relationships in normal and neoplastic prostateThe Prostate, 1991
- 1H MR spectroscopy of normal and malignant human prostates in VivoJournal of Magnetic Resonance (1969), 1990
- Localized high‐resolution proton NMR spectroscopy using stimulated echoes: Initial applications to human brain in vivoMagnetic Resonance in Medicine, 1989
- Prostate epithelial cells utilize glucose and aspartate as the carbon sources for net citrate productionThe Prostate, 1989
- In Vivo13C NMR Spectroscopy of the Human ProstateMagnetic Resonance in Medicine, 1988