Randomized trial of automated, electronic monitoring to facilitate early detection of sepsis in the intensive care unit*
- 1 July 2012
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Critical Care Medicine
- Vol. 40 (7), 2096-2101
- https://doi.org/10.1097/ccm.0b013e318250a887
Abstract
Objective: To determine whether automated identification with physician notification of the systemic inflammatory response syndrome in medical intensive care unit patients expedites early administration of new antibiotics or improvement of other patient outcomes in patients with sepsis. Design: A prospective randomized, controlled, single center study. Setting: Medical intensive care unit of an academic, tertiary care medical center. Patients: Four hundred forty-two consecutive patients admitted over a 4-month period who met modified systemic inflammatory response syndrome criteria in a medical intensive care unit. Intervention: Patients were randomized to monitoring by an electronic “Listening Application” to detect modified (systemic inflammatory response syndrome) criteria vs. usual care. The listening application notified physicians in real time when modified systemic inflammatory response syndrome criteria were detected, but did not provide management recommendations. Measurements and Main Results: The median time to new antibiotics was similar between the intervention and usual care groups when comparing among all patients (6.0 hr vs. 6.1 hr, p = .95), patients with sepsis (5.3 hr vs. 5.1 hr; p = .90), patients on antibiotics at enrollment (5.2 hr vs. 7.0 hr, p = .27), or patients not on antibiotics at enrollment (5.2 hr vs. 5.1 hr, p = .85). The amount of fluid administered following detection of modified systemic inflammatory response syndrome criteria was similar between groups whether comparing all patients or only patients who were hypotensive at enrollment. Other clinical outcomes including intensive care unit length of stay, hospital length of stay, and mortality were not shown to be different between patients in the intervention and control groups. Conclusions: Realtime alerts of modified systemic inflammatory response syndrome criteria to physicians in one tertiary care medical intensive care unit were feasible and safe but did not influence measured therapeutic interventions for sepsis or significantly alter clinical outcomes.Keywords
This publication has 19 references indexed in Scilit:
- Computerized decision support system improves fluid resuscitation following severe burns: An original study*Critical Care Medicine, 2011
- Implementation of a real-time computerized sepsis alert in nonintensive care unit patients*Critical Care Medicine, 2011
- Prospective Trial of Real-Time Electronic Surveillance to Expedite Early Care of Severe SepsisAnnals of Emergency Medicine, 2011
- Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department*Critical Care Medicine, 2010
- A systems approach to the early recognition and rapid administration of best practice therapy in sepsis and septic shockCurrent Opinion in Critical Care, 2009
- Validation of an electronic surveillance system for acute lung injuryIntensive Care Medicine, 2009
- Hospital-wide impact of a standardized order set for the management of bacteremic severe sepsis*Critical Care Medicine, 2009
- Improvement in Process of Care and Outcome After a Multicenter Severe Sepsis Educational Program in SpainJAMA, 2008
- Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality*Critical Care Medicine, 2007
- Before–after study of a standardized hospital order set for the management of septic shock*Critical Care Medicine, 2006