The efficacy of retinoic acid ointment for treatment of xerophthalmia and corneal epithelial wounds
- 1 January 1985
- journal article
- Published by Taylor & Francis Ltd in Current Eye Research
- Vol. 4 (10), 1049-1057
- https://doi.org/10.3109/02713688509003350
Abstract
In previous studies of topical application of retinoic acid to the eye, retinoic acid in an oil vehicle has been used. An all-trans-retinoic acid (Tretinoin, USP) formulation in a petrolatum-based ophthalmic ointment vehicle has now been developed which is chemically stable for at least one year. The ointment is effective at retinoic acid concentrations of 0.01–0.1% in reversing corneal keratinization in vitamin Adeficient, xerophthalmic rabbits. At 0.1% it also stimulates the healing rate of corneal epithelial wounds in rabbits and monkeys. Retinoic acid ointment may prove to be valuable clinically in the treatment of xerophthalmia, corneal epithelial erosions, and related ocular surface abnormalities.Keywords
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