Primary Prevention of Stroke by Healthy Lifestyle
Top Cited Papers
- 26 August 2008
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 118 (9), 947-954
- https://doi.org/10.1161/circulationaha.108.781062
Abstract
Background— The combination of healthy lifestyle factors is associated with lower risk of coronary heart disease, diabetes, and total cardiovascular disease. Little is known about the impact of multiple lifestyle factors on the risk of stroke. Methods and Results— We conducted a prospective cohort study among 43 685 men from the Health Professionals Follow-up Study and 71 243 women from the Nurses’ Health Study. Diet and other lifestyle factors were updated from self-reported questionnaires. We defined a low-risk lifestyle as not smoking, a body mass index 2 , ≥30 min/d of moderate activity, modest alcohol consumption (men, 5 to 30 g/d; women, 5 to 15 g/d), and scoring within the top 40% of a healthy diet score. We documented 1559 strokes (853 ischemic, 278 hemorrhagic) among women and 994 strokes (600 ischemic, 161 hemorrhagic) among men during follow-up. Women with all 5 low-risk factors had a relative risk of 0.21 (95% confidence interval [CI], 0.12, 0.36) for total and 0.19 (95% CI, 0.09, 0.40) for ischemic stroke compared with women who had none of these factors. Among men, the relative risks were 0.31 (95% CI, 0.19, 0.53) for total and 0.20 (95% CI, 0.10, 0.42) for ischemic stroke for the same comparison. Among the women, 47% (95% CI, 18 to 69) of total and 54% (95% CI, 15 to 78%) of ischemic stroke cases were attributable to lack of adherence to a low-risk lifestyle; among the men, 35% (95% CI, 7 to 58) of total and 52% (95% CI, 19 to 75) of ischemic stroke may have been prevented. Conclusion— A low-risk lifestyle that is associated with a reduced risk of multiple chronic diseases also may be beneficial in the prevention of stroke, especially ischemic stroke.This publication has 37 references indexed in Scilit:
- U.S. Department of Agriculture and U.S. Department of Health and Human Services, Dietary Guidelines for Americans, 2010. 7th Edition, Washington, DC: U.S. Government Printing Office, January 2011Advances in Nutrition: An International Review Journal, 2011
- The Case for Modality-Specific Outcome Measures in Clinical Trials of Stroke Recovery-Promoting AgentsStroke, 2007
- Point and interval estimates of partial population attributable risks in cohort studies: examples and softwareCancer Causes & Control, 2007
- Healthy Lifestyle Factors in the Primary Prevention of Coronary Heart Disease Among MenCirculation, 2006
- Primary Prevention of Ischemic StrokeStroke, 2006
- Prevalence of Overweight and Obesity in the United States, 1999-2004JAMA, 2006
- Abdominal Obesity and Risk of Ischemic StrokeStroke, 2003
- Primary Prevention of Coronary Heart Disease in Women through Diet and LifestyleThe New England Journal of Medicine, 2000
- A prospective study of parental history off myocardial infarction and coronary artery disease in menThe American Journal of Cardiology, 1991
- Relative and Absolute Excess Risks of Coronary Heart Disease among Women Who Smoke CigarettesThe New England Journal of Medicine, 1987