Nationwide prevalence and incidence study of neuromyelitis optica spectrum disorder in Denmark
Open Access
- 11 December 2018
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 91 (24), e2265-e2275
- https://doi.org/10.1212/wnl.0000000000006645
Abstract
Objectives To estimate the nationwide population-based incidence, prevalence, and geographical distribution of neuromyelitis optica (NMO) spectrum disorder (NMOSD) in Denmark based on the 2015 International Panel for NMO Diagnosis (IPND) criteria. Methods We conducted a multicentre, historically prospective study. Data were sourced from the Danish National Patient Registry, the Danish Multiple Sclerosis Registry, departments of neurology, and laboratories providing aquaporin-4 antibody test. Cases were selected based on the 2006 Wingerchuk and the 2015 IPND criteria and were individually validated by an expert panel. Results We confirmed NMO in 30 cases (2006 criteria) and NMOSD in 56 cases (2015 IPND criteria) between 2007 and 2014. Defined by the 2006 criteria, the incidence of NMO was 0.029 per 100,000 person-years (95% confidence interval [CI] 0.014–0.051), and the prevalence (aged 16 years and older) was 0.566 per 100,000 (95% CI 0.370–0.830). Based on the 2015 IPND criteria, the incidence of NMOSD was 0.070 per 100,000 person-years (95% CI 0.046–0.102), and the prevalence (aged 16 years and older) was 1.09 per 100,000 (95% CI 0.808–1.440), without regional differences. Conclusions Our estimates of incidence and prevalence are similar to other Caucasian population–based studies using the 2015 IPND criteria. We found no geographical clustering in Denmark.Keywords
This publication has 33 references indexed in Scilit:
- Epidemiology of NMOSD in Catalonia: Influence of the new 2015 criteria in incidence and prevalence estimatesMultiple Sclerosis Journal, 2018
- International consensus diagnostic criteria for neuromyelitis optica spectrum disordersNeurology, 2015
- MOG cell-based assay detects non-MS patients with inflammatory neurologic diseaseNeurology Neuroimmunology & Neuroinflammation, 2015
- An epidemiological study of neuromyelitis optica in IsfahanMultiple Sclerosis Journal, 2014
- Observation Period Effects on Estimation of Systemic Lupus Erythematosus Incidence and Prevalence in QuebecThe Journal of Rheumatology, 2013
- The epidemiology of neuromyelitis optica amongst adults in the Merseyside county of United KingdomZeitschrift für Neurologie, 2013
- Increased prevalence, incidence, and female predominance of multiple sclerosis in northern JapanJournal of the Neurological Sciences, 2012
- The prevalence of neuromyelitis optica in South East WalesEuropean Journal of Neurology, 2011
- Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosisBrain, 2007
- Revised diagnostic criteria for neuromyelitis opticaNeurology, 2006