Citrus Fruit Intake Is Associated with Lower Serum Bilirubin Concentration among Women with the UGT1A1*28 Polymorphism
Open Access
- 1 March 2009
- journal article
- Published by Oxford University Press (OUP) in Journal of Nutrition
- Vol. 139 (3), 555-560
- https://doi.org/10.3945/jn.108.097279
Abstract
UDP-glucuronosyltransferase (UGT) 1A1 glucuronidates bilirubin, estrogens, and xenobiotic compounds. The UGT1A1*28 polymorphism results in lower promoter activity due to 7 thymine-adenine (TA) repeats rather than the more common 6 TA repeats. Previously, we showed that serum bilirubin, a marker of UGT1A1 activity, was lower among individuals homozygous for the UGT1A1*28 polymorphism (7/7) when randomized to a high fruit and vegetable (F&V) diet, whereas there was no effect in individuals with the wild-type (6/6) and heterozygous (6/7) genotypes. Our objective here was to determine if we could detect genotype × diet interactions on bilirubin concentrations in an observational study. Healthy nonsmoking men (n = 146) and women (n = 147), recruited from the Seattle area, provided blood samples for genotyping and bilirubin measurements. We used multiple linear regression to assess the relationships among UGT1A1 genotype, bilirubin concentrations, and consumption of specific F&V [cruciferous vegetables, citrus fruits, and soy foods (n = 268)] based on FFQ and F&V from 6 botanical families [Cruciferae, Rosaceae, Rutaceae, Umbelliferae, Solanaceae, and Leguminosae (n = 261)] based on 3-d food records. We observed a significant interaction of UGT1A1 genotype and citrus consumption among women. Women with the 7/7 genotype who consumed ≥0.5 daily servings of citrus fruit or foods from the Rutaceae botanical family had ∼30% lower serum bilirubin than those with the same genotype who consumed less, whereas 6/6 and 6/7 genotypes did not differ by consumption (P for interaction = 0.006 and 0.03, respectively). These results suggest that citrus consumption may increase UGT1A1 activity among women with the 7/7 genotype.Keywords
This publication has 65 references indexed in Scilit:
- UGT1A1 and UGT1A9 functional variants, meat intake, and colon cancer, among Caucasians and African-AmericansMutation research. Reviews in mutation research, 2008
- Intrinsic AhR function underlies cross-talk of dioxins with sex hormone signalingsBiochemical and Biophysical Research Communications, 2008
- Regulation of UDP-glucuronosyltransferase (UGT) 1A1 by progesterone and its impact on labetalol eliminationXenobiotica, 2008
- Cytochrome P450 1A1 Expression and Activity in Caco-2 Cells: Modulation by Apple Juice Extract and Certain Apple PolyphenolsJournal of Agricultural and Food Chemistry, 2006
- Estrogen receptor and aryl hydrocarbon receptor signaling pathwaysNuclear Receptor Signaling, 2006
- Cancer chemoprevention with dietary phytochemicalsNature Reviews Cancer, 2003
- Induction of rat hepatic and intestinal UDP-glucuronosyltransferases by naturally occurring dietary anticarcinogensCarcinogenesis: Integrative Cancer Research, 2003
- Expression of CYP1A1 and CYP1B1 depends on cell-specific factors in human breast cancer cell lines: role of estrogen receptor statusCarcinogenesis: Integrative Cancer Research, 1999
- TIME COURSE OF INDUCTION OF RAT HEPATIC DRUG METABOLIZING ENZYME ACTIVITIES FOLLOWING DIETARY ADMINISTRATION OF FLAVONOIDSJournal of Toxicology and Environmental Health, 1996
- Dietary modification of drug‐metabolizing enzyme activities: Dose‐response effect of flavonoidsJournal of Toxicology and Environmental Health, 1992