Periodontopathic Bacteria in Children With Down Syndrome
- 1 February 2000
- journal article
- Published by Wiley in The Journal of Periodontology
- Vol. 71 (2), 249-255
- https://doi.org/10.1902/jop.2000.71.2.249
Abstract
Background: It is widely known that individuals with Down syndrome (DS) often develop severe early‐onset periodontal diseases. In this study, we examined the prevalence of periodontopathic bacteria in DS children to determine if specific pathogens are acquired in their childhood. Methods: The subjects were 60 DS children (2 to 13 years old, 5 in each age bracket) and 60 age‐matched controls. Ten pathogens, Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Bacteroides forsythus, Treponema denticola, Prevotella intermedia, P. nigrescens, Capnocytophaga ochracea, C. sputigena, Campyrobacter rectus, and Eikenella corrodens were surveyed in subgingival plaque samples using a polymerase chain reaction. Periodontal status was evaluated by probing depth, bleeding on probing, and gingival index. Results: No significant difference in periodontal status was observed between the DS and control groups, however, all of the pathogens were detected with greater frequency in the DS children. B. forsythus, T. denticola, P. nigrescens, and C. rectus were significantly prevalent throughout all age brackets of the DS children (P P. gingivalis was also significant in the DS subjects over 5 years old. A cluster analysis of the microbial profiles of the DS subjects showed that gingivitis severity was associated with increased varieties of the harboring pathogens and the distribution of P. gingivalis. Conclusions: These results suggest that various periodontopathogens can colonize in the very early childhood of DS patients and maturation of subgingival components, including P. gingivalis, plays an important role in the initiation of gingival inflammation. J Periodontol 2000;71:249‐255.Keywords
This publication has 28 references indexed in Scilit:
- Early‐Onset Periodontitis Associated With Down's Syndrome–A Clinical Interventional StudyAnnals of Periodontology, 1998
- Polymerase chain reaction detection of 8 putative periodontal pathogens in subgingival plaque of gingivitis and advanced periodontitis lesionsOral Microbiology and Immunology, 1996
- Porphyromonas gingivaiis, Actinobacillus actinomycetemeomitans and Treponema denticola detection in oral plaque samples using the polymerase chain reactionJournal of Clinical Periodontology, 1996
- Actinobacillus actinomycetemcomitans, Capnocytophaga and Porphyromonas gingivalis in subgingival plaque of adolescents with Down's syndromeOral Microbiology and Immunology, 1992
- Caries levels, Streptococcus mutans counts, salivary pH, and periodontal treatment needs of adult Down syndrome patientsSpecial Care in Dentistry, 1991
- Distribution of Actinobacillus actinomycetemcomitans serotypes in periodontal health and diseaseOral Microbiology and Immunology, 1991
- Caries experience, periodontal treatment needs, salivary pH, and Streptococcus mutans counts in a preadolescent Down syndrome populationSpecial Care in Dentistry, 1991
- Periodontal disease in Down's syndrome: a reviewJournal of Clinical Periodontology, 1986
- An annotated review of the literature of dental caries and periodontal disease in mentally retarded individualsSpecial Care in Dentistry, 1981
- The Plaque Control RecordThe Journal of Periodontology, 1972