Human Platelet-Derived Growth Factor (PDGF): Amino-Terminal Amino Acid Sequence
- 27 May 1983
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 220 (4600), 963-965
- https://doi.org/10.1126/science.6844921
Abstract
Human platelet-derived growth factor (PDGF) obtained from outdated human platelets was subjected to amino-terminal amino acid sequence analysis by automated Edman degradation. Despite the apparent presence of limited proteolytic degradation of the protein derived from this method, the sequence analysis reveals two primary peptide sequences and suggests that active PDGF is composed of two, possibly homologous, peptides linked by a disulfide bond or bonds.Keywords
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