Diabetes insipidus revealing acute myelogenous leukaemia with a high platelet count, monosomy 7 and abnormalities of chromosome 3: a new entity?
- 1 January 2001
- journal article
- case report
- Published by Wiley in European Journal of Haematology
- Vol. 66 (1), 66-69
- https://doi.org/10.1034/j.1600-0609.2001.00346.x
Abstract
We describe three cases of acute myeloid leukaemia revealed by diabetes insipidus. The patients were 42, 38 and 39 yr old and they had marked hyperleukocytosis, circulating immature granular cells and a normal or elevated platelet count. The leukaemia was type AML‐M2 according to the FAB classification. Cytogenetic studies showed inversion of chromosome 3 (q21;q26) in 2 cases and a translocation (3;3)(q21;q29?) in the remaining case, both associated with monosomy 7. All the cerebral CT scans were normal. Complete remission was never achieved, and all three patients survived less than 14 months. Desmopressine therapy was active but treatment could not be reduced. The association of dysmegacaryopoiesis with a chromosome 3 abnormality and diabetes insipidus is probably not fortuitous and could represent a new entity.Keywords
This publication has 14 references indexed in Scilit:
- Central diabetes insipidus preceding acute myeloid leukemia with t(3;12)(q26;p12)Stroke Prevention in Atrial Fibrillation, 2000
- The Evil proto-oncogene is required at midgestation for neural, heart, and paraxial mesenchyme developmentMechanisms of Development, 1997
- Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26.Proceedings of the National Academy of Sciences of the United States of America, 1992
- Acute myelogenous leukemia (AML) and diabetes insipidus (DI): Further association with monosomy 7Hematological Oncology, 1992
- Three new cases of chromosome 3 rearrangement in bands q21 and q26 with abnormal thrombopoiesis bring further evidence to the existence of a 3q21q26 syndromeCancer Genetics and Cytogenetics, 1992
- Monosomy 7 predisposes to diabetes insipidus in leukaemia and myelodysplastic syndromeEuropean Journal of Haematology, 1987
- HUMAN PLATELET ARGININE VASOPRESSINClinical Endocrinology, 1986
- Clinical Significance of Chromosomal Abnormalities in Acute Nonlymphoblastic LeukemiaCancer Genetics and Cytogenetics, 1984
- Abnormalities of Chromosome 7 Resulting in Monosomy 7 or in Deletion of the Long Arm (7q-): Review of Translocations, Breakpoints, and Associated AbnormalitiesCancer Genetics and Cytogenetics, 1984
- Diabetes Insipidus Associated With Central Nervous System LeukemiaSouthern Medical Journal, 1982