Tyrosinase related protein 1 (TYRP1/gp75) in human cutaneous melanoma
Open Access
- 3 February 2011
- journal article
- review article
- Published by Wiley in Molecular Oncology
- Vol. 5 (2), 150-155
- https://doi.org/10.1016/j.molonc.2011.01.006
Abstract
Melanoma prognosis is based on specific pathological features at the primary lesion. In metastatic patients, the extent of lymph node involvement is also an important prognosis indicator. Many progression markers both in tissues and serum, including circulating tumor cells, have been studied and new molecular markers are awaited from high‐throughput screenings to discriminate between clinical stages and predict disease progression. The present review focuses on human tyrosinase related protein 1 also known as gp75 glycoprotein (Tyrp1/gp75), a melanosomal protein involved in the pigmentary machinery of the melanocyte and often used as differentiation marker, with a special emphasis on its emerging roles in the malignant melanocyte and melanoma progression.Keywords
This publication has 67 references indexed in Scilit:
- Multiple Pigmentation Gene Polymorphisms Account for a Substantial Proportion of Risk of Cutaneous Malignant MelanomaJournal of Investigative Dermatology, 2010
- Selection criteria for genetic assessment of patients with familial melanomaJournal of the American Academy of Dermatology, 2009
- ESCRT‐I Function is Required for Tyrp1 Transport from Early Endosomes to the Melanosome Limiting MembraneTraffic, 2009
- Varp Is a Novel Rab32/38-binding Protein That Regulates Tyrp1 Trafficking in MelanocytesMolecular Biology of the Cell, 2009
- Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in CaucasiansInternational Journal of Cancer, 2009
- Improved Tumor Immunity Using Anti-Tyrosinase Related Protein-1 Monoclonal Antibody Combined with DNA Vaccines in Murine MelanomaCancer Research, 2008
- A Role for Tyrosinase-Related Protein 1 in 4-tert-Butylphenol-Induced Toxicity in Melanocytes: Implications for VitiligoThe American Journal of Pathology, 2006
- Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymesThe Journal of cell biology, 2006
- Optimization of a self antigen for presentation of multiple epitopes in cancer immunityJCI Insight, 2006
- Cotransfection of Genes Encoding Human Tyrosinase and Tyrosinase-Related Protein-1 Prevents Melanocyte Death and Enhances Melanin Pigmentation and Gene Expression of Lamp-1Experimental Cell Research, 1994