Interim results of an ecological experiment — Conjugate vaccination against the pneumococcus and serotype replacement
Open Access
- 26 August 2015
- journal article
- review article
- Published by Informa UK Limited in Human Vaccines & Immunotherapeutics
- Vol. 12 (2), 358-374
- https://doi.org/10.1080/21645515.2015.1118593
Abstract
Streptococcus pneumoniae has more than 95 serotypes, each of which presumably can cause sepsis, meningitis, pneumonia, and acute otitis media. Pneumococcal conjugate vaccines (PCV) targeted against a limited number of serotypes have nonetheless revealed an impressive impact on each manifestation of pneumococcal disease. At the same time, growing evidence of significant non-vaccine type (NVT) replacement disease following implementation of infant PCV programs has raised questions about the long-term viability of PCV immunization strategies and how to optimize PCV formulations. We discuss here theoretical and practical considerations regarding serotype replacement, and provide a snapshot of the most important NVT types seen to date after implementation of the 2 higher-valent PCVs.Keywords
This publication has 85 references indexed in Scilit:
- Effects of the 10-Valent Pneumococcal Nontypeable Haemophilus influenzae Protein D-Conjugate Vaccine on Nasopharyngeal Bacterial Colonization in Young Children: A Randomized Controlled TrialClinical Infectious Diseases, 2012
- Rates of Acquisition and Clearance of Pneumococcal Serotypes in the Nasopharynges of Children in Kilifi District, KenyaThe Journal of Infectious Diseases, 2012
- Niche and Neutral Effects of Acquired Immunity Permit Coexistence of Pneumococcal SerotypesScience, 2012
- Effects of Community-Wide Vaccination with PCV-7 on Pneumococcal Nasopharyngeal Carriage in The Gambia: A Cluster-Randomized TrialPLoS Medicine, 2011
- High Levels of Recombination among Streptococcus pneumoniae Isolates from the GambiamBio, 2011
- Serotype replacement in disease after pneumococcal vaccinationThe Lancet, 2011
- Evidence that pneumococcal serotype replacement in Massachusetts following conjugate vaccination is now completeEpidemics, 2010
- What is the mechanism for persistent coexistence of drug-susceptible and drug-resistant strains of Streptococcus pneumoniae ?Journal of The Royal Society Interface, 2009
- No coexistence for free: Neutral null models for multistrain pathogensEpidemics, 2009
- Invasive Pneumococcal Disease Caused by Nonvaccine Serotypes Among Alaska Native Children With High Levels of 7-Valent Pneumococcal Conjugate Vaccine CoverageJAMA, 2007