Telomere shortening and survival in free-living corvids
- 11 June 2009
- journal article
- Published by The Royal Society in Proceedings Of The Royal Society B-Biological Sciences
- Vol. 276 (1670), 3157-3165
- https://doi.org/10.1098/rspb.2009.0517
Abstract
Evidence accumulates that telomere shortening reflects lifestyle and predicts remaining lifespan, but little is known of telomere dynamics and their relation to survival under natural conditions. We present longitudinal telomere data in free-living jackdaws (Corvus monedula) and test hypotheses on telomere shortening and survival. Telomeres in erythrocytes were measured using pulsed-field gel electrophoresis. Telomere shortening rates within individuals were twice as high as the population level slope, demonstrating that individuals with short telomeres are less likely to survive. Further analysis showed that shortening rate in particular predicted survival, because telomere shortening was much accelerated during a bird's last year in the colony. Telomere shortening was also faster early in life, even after growth was completed. It was previously shown that the lengths of the shortest telomeres best predict cellular senescence, suggesting that shorter telomeres should be better protected. We test the latter hypothesis and show that, within individuals, long telomeres shorten faster than short telomeres in adults and nestlings, a result not previously shown in vivo. Moreover, survival selection in adults was most conspicuous on relatively long telomeres. In conclusion, our longitudinal data indicate that the shortening rate of long telomeres may be a measure of 'life stress' and hence holds promise as a biomarker of remaining lifespan.Keywords
This publication has 69 references indexed in Scilit:
- Telomere dynamics rather than age predict life expectancy in the wildProceedings Of The Royal Society B-Biological Sciences, 2009
- Leukocyte Telomere Dynamics: Longitudinal Findings Among Young Adults in the Bogalusa Heart StudyAmerican Journal of Epidemiology, 2008
- Metabolic ageing in individual zebra finchesBiology Letters, 2008
- Telomere Length and Mortality: A Study of Leukocytes in Elderly Danish TwinsAmerican Journal of Epidemiology, 2008
- The nature of telomere fusion and a definition of the critical telomere length in human cellsGenes & Development, 2007
- Stress impacts telomere dynamicsBiology Letters, 2007
- Telomerase activity coevolves with body mass not lifespanAging Cell, 2006
- Longer telomeres associated with higher survival in birdsBiology Letters, 2005
- A DNA damage checkpoint response in telomere-initiated senescenceNature, 2003
- Extensive allelic variation and ultrashort telomeres in senescent human cellsNature Genetics, 2003