Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing
Top Cited Papers
- 3 June 2015
- journal article
- practice guideline
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 98 (1), 19-24
- https://doi.org/10.1002/cpt.113
Abstract
Tacrolimus is the mainstay immunosuppressant drug used after solid organ and hematopoietic stem cell transplantation. Individuals who express CYP3A5 (extensive and intermediate metabolizers) generally have decreased dose‐adjusted trough concentrations of tacrolimus as compared with those who are CYP3A5 nonexpressers (poor metabolizers), possibly delaying achievement of target blood concentrations. We summarize evidence from the published literature supporting this association and provide dosing recommendations for tacrolimus based on CYP3A5 genotype when known (updates at www.pharmgkb.org).Keywords
This publication has 41 references indexed in Scilit:
- CYP3A5 Polymorphism in Mexican Renal Transplant Recipients and its Association with Tacrolimus DosingArchives of Medical Research, 2012
- Age and CYP3A5 genotype affect tacrolimus dosing requirements after transplant in pediatric heart recipientsThe Journal of Heart and Lung Transplantation, 2011
- Influence of CYP3A5 polymorphism on tacrolimus maintenance doses and serum levels after renal transplantation: Age dependency and pharmacological interaction with steroidsPediatric Transplantation, 2011
- The interactions of age, genetics, and disease severity on tacrolimus dosing requirements after pediatric kidney and liver transplantationEuropean Journal of Clinical Pharmacology, 2011
- CYP3A5*1/*3 genotype influences the blood concentration of tacrolimus in response to metabolic inhibition by ketoconazolePharmacogenetics and Genomics, 2009
- Effects of CYP3A5 and MDR1 single nucleotide polymorphisms on drug interactions between tacrolimus and fluconazole in renal allograft recipientsPharmacogenetics and Genomics, 2008
- Impact of MDR1 and CYP3A5 on the oral clearance of tacrolimus and tacrolimus-related renal dysfunction in adult living-donor liver transplant patientsPharmacogenetics and Genomics, 2008
- Standard dosing of tacrolimus leads to overexposure in pediatric renal transplantation recipientsPediatric Transplantation, 2008
- Tacrolimus dose requirement in relation to donor and recipientABCB1 andCYP3A5 gene polymorphisms in Chinese liver transplant patientsLiver Transplantation, 2006
- RELATIONSHIP OF FK506 WHOLE BLOOD CONCENTRATIONS AND EFFICACY AND TOXICITY AFTER LIVER AND KIDNEY TRANSPLANTATIONTransplantation, 1996