In vitro biocompatibility of fluorcanasite glass‐ceramics for bone tissue repair
Open Access
- 3 October 2006
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research Part A
- Vol. 80A (1), 175-183
- https://doi.org/10.1002/jbm.a.30878
Abstract
Fluorcanasite glass-ceramics were produced by controlled two stage heat-treatment of as-cast glasses. These glasses were modified from stoichiometric fluorcanasite composition by either adding P2O5 or altering the molar ratios of Na2O and CaO. Commercial bioactive 45S5 Bioglass® was also prepared in-house to evaluate the relative in vitro biocompatibility of fluorcanasite glass-ceramics. The scanning electron microscopy (SEM) images showed that cells had colonized the surfaces of fluorcanasite glass-ceramics to form a confluent sheet. Quantitative MTT assay results were in good agreement with the qualitative SEM observations. It was concluded that incorporation of excess calcium oxide or P2O5 in stoichiometric glass composition improved in vitro biocompatibility. Controlled heat-treatment further improved the biological response of cultured bone cells to modified fluorcanasite glass-ceramics when compared with their parent glasses. Ion release and pH data suggested a strong correlation between solubility (in particular, Na ion release) and biocompatibility. Reduced solubility, Na ion release, and related pH effects appeared to be the principal mechanisms responsible for improvement in in vitro biocompatibility. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2007Keywords
This publication has 15 references indexed in Scilit:
- Formation of apatite layers on modified canasite glass–ceramics in simulated body fluidJournal of Biomedical Materials Research, 2001
- Influence of sodium oxide content on bioactive glass propertiesJournal of Materials Science: Materials in Medicine, 1999
- Dependence of in vitro biocompatibility of ionomeric cements on ion releaseJournal of Materials Science: Materials in Medicine, 1998
- Role of exchanged ions in the integration of ionomeric (glass polyalkenoate) bone substitutesBiomaterials, 1997
- Apatite-mullite glass-ceramicsJournal of Materials Science: Materials in Medicine, 1995
- A/W GLASS-CERAMIC: PROCESSING AND PROPERTIESPublished by World Scientific Pub Co Pte Ltd ,1993
- Bioactivity of CaO·SiO2 glasses added with various ionsJournal of Materials Science: Materials in Electronics, 1992
- Mechanism of apatite formation on CaO SiO2P2O5 glasses in a simulated body fluidJournal of Non-Crystalline Solids, 1992
- Bioceramics: From Concept to ClinicJournal of the American Ceramic Society, 1991
- Chain silicate glass-ceramicsJournal of Non-Crystalline Solids, 1991