Tumour budding, uPA and PAI‐1 are associated with aggressive behaviour in colon cancer
- 24 May 2010
- journal article
- research article
- Published by Wiley in Journal of Surgical Oncology
- Vol. 102 (3), 235-241
- https://doi.org/10.1002/jso.21611
Abstract
Aims The proteases PAI-1 and uPA play a major role in extracellular matrix degradation, which facilitates tumour progression. Tumour budding is a histomorphological expression of enhanced tumour cell migration. Materials and Methods To investigate their prognostic value for and correlation with colon cancer, a prospective study was performed. We analysed tissue levels of uPA and PAI-1 of 55 colon cancer tumours employing a commercially available enzyme-linked immunosorbent assay (ELISA). Tumour budding was analysed on cytokeratin-stained slides. Results There was a strong correlation between uPA and tumour budding (R = 0.440; P < 0.001). uPA levels were increased in high grade tumours, whereas PAI-1 was elevated in cases with venous invasion (P = 0.004 and P = 0.028). PAI-1 values and tumour budding are associated significantly with the occurrence of distant metastases (P < 0.001 and P = 0.034, respectively). Tumour budding was significantly associated with lymph node metastases (P = 0.034). Multivariate analysis revealed PAI-1 and lymph node metastases to be independently predictive of distant metastases (P = 0.007 and P = 0.004, respectively). Conclusions The results of our study show that tumour budding and the plasmin/plasminogen system are related. PAI-1 was independently predictive for the occurrence of distant metastasis. J. Surg. Oncol. 2010;102:235–241.Keywords
This publication has 34 references indexed in Scilit:
- Clinical Cancer Advances 2008: Major Research Advances in Cancer Treatment, Prevention, and Screening—A Report From the American Society of Clinical OncologyJournal of Clinical Oncology, 2009
- Methylene Blue–Assisted Lymph Node Dissection in Colon SpecimensAmerican Journal of Clinical Pathology, 2008
- Evolving role of uPA/uPAR system in human cancersCancer Treatment Reviews, 2008
- Regulation of programmed cell death by plasminogen activator inhibitor type 1 (PAI-1)Thrombosis and Haemostasis, 2008
- American Society of Clinical Oncology 2007 Update of Recommendations for the Use of Tumor Markers in Breast CancerJournal of Clinical Oncology, 2007
- Expression of E-Cadherin and uPA and their Association with the Prognosis of Pancreatic CancerJapanese Journal of Clinical Oncology, 2005
- Colon Cancer Survival Rates With the New American Joint Committee on Cancer Sixth Edition StagingJNCI Journal of the National Cancer Institute, 2004
- Plasmin/Plasminogen System in Colorectal CancerWorld Journal of Surgery, 2002
- Preoperative plasma plasminogen activator inhibitor type-1 and serum C-reactive protein levels in patients with colorectal cancerAnnals of Surgical Oncology, 2000
- Detection of lymph node metastases in colorectal carcinoma before and after fat clearanceBritish Journal of Surgery, 1989