Comparing oxygen-sensitive MRI (BOLD R2*) with oxygen electrode measurements: A pilot study in men with prostate cancer
- 1 January 2009
- journal article
- clinical trial
- Published by Taylor & Francis Ltd in International Journal of Radiation Biology
- Vol. 85 (9), 805-813
- https://doi.org/10.1080/09553000903043059
Abstract
Purpose: To explore the relationship between oxygen-sensitive Magnetic Resonance Imaging (MRI) and oxygen measurements in prostate cancer. Methods: Nine men underwent MRI examinations followed by needle oxygen measurements of tumor bearing region within prostate gland and five men further consented to biopsy. Median pO2 and hypoxic fraction < 5 mm Hg (HP5) were derived. Biopsies were immunostained for Carbonic Anhydrase IX (CA IX), Hypoxia Inducible Factor-1 (HIF 1) and Glucose Transporter-1 (GLUT 1). Corresponding Regions-of-Interest (ROI) were delineated on T2-weighted (T2w) MRI by two observers. Median R2* was calculated for each ROI. Spearman correlation was calculated between R2* and HP5/pO2. Results: MRI quality evaluation resulted in exclusion of 4/18 ROI due to motion (n = 2) and rectal air susceptibility artifact (n = 2). Quality of remaining data was validated by concordance of R2* with T2w, indices and with secondary observer R2* (r = 0.94, p = 0.005). Correlation was observed between R2* and HP5 (r = 0.76, p = 0.02) and a trend was noted between R2* and pO2 (r = −0.66, p = 0.07). GLUT 1 and HIF 1 were expressed in all patients, and CA IX was expressed in one patient with high HP5 (77%) and low pO2 (1.4 mm Hg). Conclusions: MRI using R2* quantification is a promising tool for non-invasive imaging of prostate cancer hypoxia.Keywords
This publication has 45 references indexed in Scilit:
- Intrinsic markers of tumour hypoxia and angiogenesis in localised prostate cancer and outcome of radical treatment: a retrospective analysis of two randomised radiotherapy trials and one surgical cohort studyThe Lancet Oncology, 2008
- Deriving blood‐oxygen‐level‐dependent contrast in MRI with T‐weighted, T2‐prepared and phase‐cycled SSFP methods: Theory and experimentMagnetic Resonance in Medicine, 2008
- Fluorine-18-Labeled Fluoromisonidazole Positron Emission and Computed Tomography-Guided Intensity-Modulated Radiotherapy for Head and Neck Cancer: A Feasibility StudyInternational Journal of Radiation Oncology*Biology*Physics, 2008
- MRI relaxation fluctuations in acute reperfused hemorrhagic infarctionMagnetic Resonance in Medicine, 2006
- Imaging oxygenation of human tumoursEuropean Radiology, 2006
- Quantitative apparent diffusion coefficients and T2 relaxation times in characterizing contrast enhancing brain tumors and regions of peritumoral edemaJournal of Magnetic Resonance Imaging, 2005
- Prostate cancer hypoxia correlates with poor patient outcome following treatment with radiotherapyInternational Journal of Radiation Oncology*Biology*Physics, 2004
- Polarographic electrode study of tumor oxygenation in clinically localized prostate cancerInternational Journal of Radiation Oncology*Biology*Physics, 2004
- How does blood oxygen level‐dependent (BOLD) contrast correlate with oxygen partial pressure (pO2) inside tumors?Magnetic Resonance in Medicine, 2002
- Why fat is bright in rare and fast spin‐echo imagingJournal of Magnetic Resonance Imaging, 1992