Basic Experimental Studies of Ostial Patency and Local Metabolic Environment of the Maxillary Sinus
- 1 January 1994
- journal article
- review article
- Published by Taylor & Francis Ltd in Acta Oto-Laryngologica
- Vol. 114 (sup515), 7-11
- https://doi.org/10.3109/00016489409124315
Abstract
Experimental studies of human maxillary sinus gas exchange show that there is a balance between inflow of air through the maxillary ostium and local consumption as long as the functional size of the ostium is at least 5 mm2. Maxillary sinus mucosal blood flow is 30-40 m1/100 g tissue per minute, as measured in plethysmographic studies. This blood flow can bind and transport only half of the absorbed oxygen, the rest is consumed. Experimental histo- and biochemical studies of sinusitis show anaerobic mucosal metabolism with shortage of energy supply due to inadequate oxygen supply. There is no decrease in oxidative enzyme capacity of the mucosal epithellium. Analysis of organic acids in purulent secretion indicates that the high lactate and CO, concentration found is mainly the result of leucocyte glycolysis with local lactic acidosis. Both ostial occlusion and the initiation of bacterial growth in serous sinusitis may be secondary to an initial inflammatory response, resulting in local tissue pathology and swelling of the ostiomeatal complex, as well as creating the appropriate redox potential for further bacterial growth in the secretions.Keywords
This publication has 15 references indexed in Scilit:
- Lactic Acid Isomers and Fatty Acids in Sinus Secretion: A Longitudinal Study of Bacterial and Leukocyte Metabolism in Experimental SinusitisScandinavian Journal of Infectious Diseases, 1992
- The Mucociliary Activity of the Respiratory TractActa Oto-Laryngologica, 1981
- The Role Of Local Gas Composition In Pathogenesis Of Maxillary Sinus EmpyemaActa Oto-Laryngologica, 1978
- Comparative Measurements Of The Mucosal Blood Flow In The Human Maxillary Sinus By Plethysmography And By XenonActa Oto-Laryngologica, 1978
- Purulent and Non-Purulent Maxillary Sinus Secretions With Respect to pO2, pCO2and pHActa Oto-Laryngologica, 1977
- The Patency Of The Maxillary Ostium In Relation To Body PostureActa Oto-Laryngologica, 1975
- Plethysmographic Studies of the Blood Flow in the Mucosa of the Human Maxillary SinusActa Oto-Laryngologica, 1974
- Oxygen Tension in the Human Maxillary Sinus Under Normal and Pathological ConditionsActa Oto-Laryngologica, 1974
- The Functional Size of the Human Maxillary Ostium in VivoActa Oto-Laryngologica, 1974
- The Borderline Between Acute Rhinitis and SinusitisActa Oto-Laryngologica, 1967