Prostaglandin E2induces fibroblast apoptosis by modulating multiple survival pathways
Open Access
- 10 August 2009
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 23 (12), 4317-4326
- https://doi.org/10.1096/fj.08-128801
Abstract
Although the lipid mediator prostaglandin E2 (PGE2) exerts antifibrotic effects by inhibiting multiple fibroblast functions, its ability to regulate fibroblast survival is unknown. Here, we examined ...Keywords
Funding Information
- National Institutes of Health (P50 HL56402)
- National Heart, Lung, and Blood Institute
This publication has 59 references indexed in Scilit:
- Escape from the Matrix: Multiple Mechanisms for Fibroblast Activation in Pulmonary FibrosisProceedings of the American Thoracic Society, 2008
- Variable Prostaglandin E2 Resistance in Fibroblasts from Patients with Usual Interstitial PneumoniaAmerican Journal of Respiratory and Critical Care Medicine, 2008
- TGF‐β signaling: A tale of two responsesJournal of Cellular Biochemistry, 2007
- Interferon-γ Induces Fas Trafficking and Sensitization to Apoptosis in Vascular Smooth Muscle Cells via a PI3K- and Akt-Dependent MechanismThe American Journal of Pathology, 2006
- Evolving Concepts of Apoptosis in Idiopathic Pulmonary FibrosisProceedings of the American Thoracic Society, 2006
- The victorin‐induced mitochondrial permeability transition precedes cell shrinkage and biochemical markers of cell death, and shrinkage occurs without loss of membrane integrityThe Plant Journal, 2004
- Cell DeathCell, 2004
- COX‐2‐dependent stabilization of survivin in non‐small cell lung cancerThe FASEB Journal, 2003
- Survivin gene expression in early‐stage non‐small cell lung cancerThe Journal of Pathology, 2003
- Prostaglandin E2 inhibits T cell activation-induced apoptosis and Fas-mediated cellular cytotoxicity by blockade of Fas-ligand inductionEuropean Journal of Immunology, 1999